Phases of clinical trials
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Phases of clinical trials
Preclinical: Laboratory & animal models Goal: Explore if & how new treatment may work Phase I: Small number (eg, 20-100) of healthy subjects Goal: Evaluate toxicity, maximum tolerated dose, adverse effects, pharmacokinetics & pharmacodynamics of new treatment (safety) Phase II: Small number (eg, up to a few hundred) of affected subjects Goal ...
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Today, Dr. Abhishek discussed a very important topic with the students, Systematic Review, a cornerstone of evidence-based medicine. He explained that a systematic review is a structured, comprehensive, and transparent method of identifying, evaluating, and synthesizing all relevant research on a specific question. Unlike a simple review, it follows a clearly defined protocol with a pre-determined search strategy, inclusion and exclusion criteria, and critical appraisal of studies to minimize bi
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