Harry, a 68-year-old white British man, presents to his GP with a 6-month history of urinary hesitancy, weak urinary stream and nocturia. He has also noticed new lower back pain over the past 2 months and has unintentionally lost 5 kg in weight. He has no family history of prostate cancer and is not of Afro-Caribbean descent which he stresses and says “I can’t have prostate cancer! That’s too African for me!” On examination, digital rectal examination reveals a hard, irregular prostate. Blood te