Versatile gene-switch tool uses non-toxic molecule for safer research

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of ...
EMBO Press

Early-stage lung adenocarcinoma affects DNA methylation and gene expression in adjacent tissues

Early-stage lung adenocarcinoma alters DNA methylation, mRNA transcription, and protein expression in adjacent tissues, exhibiting either steep changes at the tumor boundaries or shallow changes ...

Powerful tool can map gene regulation at single-nucleotide resolution

Understanding how cells turn genes on and off is one of biology's most enduring mysteries. Now, a new technology developed by ...
Nature

Evolution of gene expression

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...
eLife

Herbivorous insects independently evolved salivary effectors to regulate plant immunity by destabilizing the malectin-LRR RLP NtRLP4

State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Zhejiang Key Laboratory of Green Plant Protection, Institute of Plant ...
Medical Xpress

Gene therapy may cure diabetic heart disease, mouse study shows

Scientists have reversed diabetic heart failure with a genetic therapy in mice and miniature human "hearts" grown from stem cells. The new gene therapy may be a promising treatment for diabetic heart ...
The New England Journal of Medicine

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency

After completing short-term follow-up studies, 14 patients were enrolled in the current study, which was designed to extend patient monitoring to ensure a total duration of 15 years, in compliance ...