Genes that encode G-protein-coupled receptors (GPCRs) and G proteins can have loss-of-function or gain-of-function mutations, which result in endocrine disorders Loss-of-function mutations in GPCRs ...

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to external stimuli and are involved in many diseases. Scientists have now used computer modeling to uncover central ...

The human genome encodes hundreds of G protein-coupled receptors (GPCRs). These form the largest group of receptors through which hormones and neurotransmitters exert their functions on our cells.

Just Because a G-Protein Coupled Receptor Has Resisted Characterization Doesn’t Mean It Can’t Be Sighted—or Hunted For drug developers, G-protein coupled receptors (GPCRs) are dearly sought trophies.

The human genome encodes hundreds of G protein-coupled receptors (GPCRs), which form the largest group of receptors that hormones and neurotransmitters exert their functions on our cells. Because of ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

GPCRs possess a heptahelical structure and support normal transmembrane cell signaling processes for growth and cellular development. They are mainly found in eukaryotes but have also been observed in ...

Receptors on cell surfaces translate an outer signal into a response inside the cell. By this, they are responsible for a plethora of essential processes in living organisms. But what if we could ...

Over the past 20 years, naturally occurring mutations that affect G protein-coupled receptors (GPCRs) have been identified, mainly in patients with endocrine diseases. The study of loss-of-function or ...

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal ...

G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior. The human genome ...