After it fills with cargo, the pit pinches off to form a clathrin-coated, membrane-bound vesicle inside the cell, which then proceeds to its proper destination. In cultured cells, hundreds of these ...
Prof. Fang-Jen S. Lee's team at National Taiwan University has discovered that an intermediate cellular metabolism molecule, glycerol, regulates the localization and function of the Golgi protein Imh1 ...
Extracellular vesicles (EVs), including exosomes, microvesicles, apoptotic bodies, and many other EV subtypes, have emerged ...
Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...
With a growing number of exosome-based delivery vehicles advancing into the clinic for therapeutics and vaccines, more effective isolation and separation strategies are needed. Finnish researchers ...
How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...
All cells, from bacteria to mammalian cells, produce extracellular vesicles—tiny membrane-enclosed packages of bioactive cargo. 1 Until relatively recently, scientists believed these organic ...
It takes just a few milliseconds: A vesicle, only a few nanometers in size and filled with neurotransmitters, approaches a cell membrane, fuses with it, and releases its chemical messengers into the ...
Cells have a clever way called clathrin-mediated endocytosis to transport cargos like growth factors across the cell membrane and into the cell. Researchers used a sophisticated fluorescence ...
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