Lynk’s zemprocitinib commercial partner, Simcere, will now continue the JAK inhibitor’s development across China in RA.

Aberrant activation of intracellular signalling pathways confers malignant properties on cancer cells. Targeting intracellular signalling pathways has been a productive strategy for drug development, ...

Scientists continue to discover treatments for atopic dermatitis, the most common form of the skin condition eczema. They’ve learned that JAK inhibitors, once reserved for other illnesses, also help ...

Mark has been thinking and writing about games since a Gameboy Pocket and a copy of Link's Awakening was first placed into his tender, seven-year-old hands. Since then, he snagged a creative writing ...

Ruxolitinib cream is the first FDA-approved JAK inhibitor for skin repigmentation in people with vitiligo, paving the way for additional oral and topical JAK inhibitors to treat this autoimmune ...

The Jak and Daxter series stands as a testament to the awesome games of the PlayStation 2 generation, and also serves as the turning point when we really started to recognize Naughty Dog as a top-tier ...

Remember Crash Bandicoot? Naughty Dog created the little marsupial that would eventually become Sony's PlayStation poster boy. His first shirtless adventure was so successful it quickly spawned a ...

Please provide your email address to receive an email when new articles are posted on . JAK inhibition carried higher malignancy risk vs. biologic DMARDs. Malignancy risk was seen in older patients ...

A meta-analysis showed no significant differences between JAK inhibitor use and TNF antagonist use in terms of the risk for serious infections or malignant neoplasms in patients with immune-mediated ...

Rob is Lead Features Editor at DualShockers, and has been playing games since hijacking his sister's NES in the early 90s. Instead of outgrowing them, decided to make a life out of ranting about them.

GameSpot may get a commission from retail offers. Jak is back for the third and purportedly final time in Jak 3, the conclusion to Naughty Dog's best-selling platforming franchise. Last year's Jak II ...