Embryonic stem (ES) cells are undifferentiated cells derived from early developing embryos; they have the potential to differentiate into numerous cell types under in vitro and in vivo conditions. The ...

Figure 1: Derivation of pluripotent epiblast stem cells (EpiSCs) from the late epiblast layer of embryos at post-implantation stages. To define further the molecular properties of EpiSCs, we performed ...

“[T]he required elements of a derivation claim have not changed other than to the extent necessary to reflect the transition from a first-to-invent to a first-to-file system of patent administration.” ...