Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

A team of researchers at Kumamoto University has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease ...

The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a ...

Researchers at the University of Cologne’s CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have discovered a promising synthetic plant ...

Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Professor Dorothee Dormann and Professor Edward Lemke of Johannes Gutenberg University ...

Explore why tau still lacks treatments despite its critical role in Alzheimer's disease and other tauopathies.

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

Representative immunofluorescence image illustrating the neuroprotective effect of USP4 knockdown in iPSC-derived motor neurons (green) carrying an ALS-linked mutation. Inhibition of USP4 (EPS8 ...

Aging is inevitable for most cell types in the human body, but hematopoietic stem cells (HSCs) seem to defy the process. They retain their self-renewing ability almost throughout an organism’s ...