Innovative cardioprotective strategies are of imminent demand. Nonfatal myocardial ischemia (MI) poses a significant risk to patients undergoing major non-cardiac surgery and these non-cardiac ...

Due to a loss of functionality in hematopoietic stem cells, immune defects occur during aging. Now, researchers have identified gene Per2, whose deletion leads to a stabilization of the number of ...

Researchers find that a key circadian clock controlling kinase, CK1D -- controlling the stability of PER2 -- has two forms, one that stabilizes PER2 and one that destabilizes it. A long-studied factor ...

Whereas circadian period length in Drosophila melanogaster is directly connected to Per protein phosphorylation and stability 4, the molecular correlate for period length in mammals is not known.

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2008 ASCO Annual Meeting. This abstract does not include a full text component.

This is a preview. Log in through your library . Abstract Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In mammals, PER2 protein abundance is regulated by ...

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation. From the heart and lungs that propel our ...