One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

In diagrams and illustrations of cells, DNA is sometimes shown as a mass in the cell's nucleus, like a bowl of ramen noodles. For many years, it's been standard practice to take images of cells that ...

After 10 years, members of the 4D Nucleome consortium have successfully completed the first phase of a project that aims to map the 3D organization of the human genome and how it changes over time, ...

In an era where the U.S. healthcare system spends $4.5T annually yet faces systemic failures, with life expectancy plummeting to a three-decade low and chronic disease rates at an all-time high, the ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

Researchers at the CNIO show that oestrogens regulate gene expression by changing DNA supercoiling. Hormone-activated ...

The artificial cell nucleus (right) constructed using the purified DNA was morphologically very similar to the natural cell nucleus derived from an egg (left). A team led by Professor Kazuo Yamagata ...

Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion. This allows specific regions to come into contact and thereby activate a gene. A ...

Left: staining for H3K27me3, which marks inactive DNA, on a nucleus of a wildtype embryo consisting of two cells Right: staining for H3K27me3, which marks inactive DNA, on a nucleus of an embryo ...

This led researchers to hypothesize that hnRNP E1 might also interact with DNA. Their results, published online on July 16 in the journal Life Science Alliance, describe a novel role for hnRNP E1 in ...

Researchers have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future ...