DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late ...
An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...
A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan.
Ideaya Biosciences Inc. has announced FDA clearance of an IND for a GSK-sponsored phase I/II trial of GSK-101 (IDE-705), a small-molecule inhibitor of Polϴ helicase, in combination with GSK's PARP ...
Consequently, RK-33, the DDX3-inhibitor with great promise as a cancer fighter, is now being seriously considered for a second therapeutic function: a broad-spectrum antiviral agent. "We know that ...
Viruses have limited genetic material -- and few proteins -- so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins. Now researchers have shown how the ...
Enrique M. De La Cruz, an international leader in molecular motor proteins and the cytoskeleton, was recently appointed the William R. Kenan, Jr. Professor of Molecular Biophysics and Biochemistry, ...
Viruses have limited genetic material—and few proteins—so all the pieces must work extra hard. Zika is a great example; the virus only produces 10 proteins. Now, in a study published in the journal ...
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