Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...
Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...
Covalent inhibitors are a specialized class of small molecules designed to form chemical bonds with their target proteins, often resulting in prolonged target engagement and enhanced potency. The ...
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