Cellular death within the infarcted core occurs rapidly due to energy depletion, resulting in the release of DAMPs such as HMGB1, ATP, and HSPs. These DAMPs engage pattern recognition receptors, ...
When inflammation in the body goes unchecked, it can cause fibrosis, or tissue scarring that may lead to organ dysfunction or ...
In response to alcohol, various cellular and molecular changes occur in the liver, contributing to hepatic steatosis, inflammation and fibrosis. Hepatocytes exhibit increased production of reactive ...