cyclic AMP and cyclic GMP are universal second messengers and are sensed by receptor proteins that contain cyclic nucleotide binding (CNB) domains. In mammal, CNB domains are found in protein kinase A ...

Studying time-series gene expression enables the identification of transient transcriptional changes, temporal patterns of a response and causal relationships between genes. Experimental design and ...

New revelations have been made on possible ways to switch genes on and off that impacts on previous understandings of the biological process of how cells interpret their DNA. Until now, it had been ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...