Megakaryocytes, which are derived from hematopoietic stem cell precursors in bone marrow, form and release platelets; these circulate in the blood for 8 to 10 days before they are removed by hepatic ...

The coagulation cascade is a finely balanced system essential for maintaining haemostasis, yet its disruption can lead to either a propensity for bleeding or an increased risk of clot formation.

Blood clotting disorders are inherited or acquired conditions that affect the body’s ability to form blood clots. Some types of blood clotting disorders may cause excessive formation of blood clots, ...

Blood has many functions and circulates throughout your body. As a result, problems with it can affect you in many ways. Some of those problems can stem from a blood disorder. These disorders can ...

For men with hemophilia B, receipt of gene therapy comprising an infusion of etranacogene dezaparvovec results in sustained endogenous factor IX expression and low annualized bleeding rates over five ...

Clotting disorders can be treated by infusing patients with clotting proteins they lack, or with drugs that replace the function of these proteins. Gene therapies may soon become another option.

Researchers at McMaster University have made a discovery in the field of hematology, providing an explanation for spontaneous and unusual blood-clotting that continues to occur despite treatment with ...

Hemophilia C, also known as factor XI deficiency, is a type of bleeding disorder. It occurs due to a deficiency in factor XI, which is a protein that plays an important role in the formation of blood ...

Hemophilia B, also known as Christmas disease, is a bleeding disorder. Its characteristic feature is a deficiency of clotting factor IX. This is a protein present in the blood that helps with ...

A recent study provides new insights into the mechanisms of coagulation in persons with haemophilia A, the most common form of haemophilia. The research team was able to show that saliva contains ...

A potentially fatal disorder which causes blood clotting has been linked to a common cold, according to researchers from the University of North Carolina School of Medicine. The team found a ...